CARE Project

COVID-19 Active Research (CARE) Project

Thank you for sharing your experiences to help advance knowledge about COVID-19, including why some people have persistent symptoms and why some respond more strongly to vaccines than others.

Enrollment is closed at this time.

We have analyzed the information that all of you provided and are putting our findings in the medical literature for wide circulation.

Are you interested to see what has been learned?

Research Results
35,278 people
joined the CARE Project to fight COVID-19

Research Results

Your contribution helped drive these insights

35,278 people contributed information about their experience with COVID infections and vaccinations and this is what we learned


COVID Symptoms

  • In 2020, when COVID testing was hard to get, fever, loss of taste and loss of smell were the symptoms most predictive of testing positive.
  • People who were at highest risk of having breathing problems were obese or had underlying respiratory disorders.

COVID Vaccines

  • All 3 vaccines (Pfizer, Moderna, and J&J) were highly effective for preventing COVID infection (95% reduction), and those of you who did get infected had much milder symptoms including protection from breakthrough infections.
  • There were very few severe side effects and many of you reacted more to the second dose than the first dose of two-dose vaccines.
  • Fewer side effects were reported by people who had a seasonal flu vaccine before their COVID vaccine.


  • People who reported having autoimmune disorders appear to have persistent COVID symptoms over 30 days, particularly fatigue.

Meet Our Experts